What are the results of CJC-1295 without DAC?

For without DAC specifically , the human evidence is thin. FDA’s review says the human studies it found were on CJC-1295 DAC , not on no-DAC forms, and it found no studies of any form in people with a disease or condition. So the honest answer is that published human outcome data for no-DAC CJC-1295 are much more limited than for DAC.

What is CJC-1295 no DAC good for?

Mechanistically, it is a growth-hormone-releasing hormone analog , so its pharmacologic purpose is to stimulate GH signaling rather than to act as a long-lasting depot. From a research standpoint, the no-DAC version is mainly useful when a shorter-acting, less prolonged signal is desired, because the DAC moiety is what creates the extended half-life seen with the DAC version.

Are peptides better with or without DAC?

Not in general. DAC is not a universal upgrade, it is a design choice that changes how long the peptide stays active. For CJC-1295, DAC extends half-life into the multi-day range , while no-DAC versions are shorter-acting. “Better” depends on the use case being studied, not on a blanket rule.

How often to inject CJC-1295 without DAC?

I can’t give you a personal injection schedule for this. There is no FDA-approved dosing regimen for any form of CJC-1295, and FDA says available clinical data are limited. What can be said factually is that no-DAC versions are shorter-acting than DAC versions, so unofficial protocols you may see online tend to be more frequent, but that is not an approved standard .

What does DAC do for CJC?

DAC is the piece that lets CJC-1295 bind to serum albumin , which dramatically extends how long it remains in circulation. In the human DAC study, the estimated half-life was about 5.8 to 8.1 days .

Should I take CJC with DAC?

I would not recommend self-using either form. No form of CJC-1295 is approved in the countries FDA reviewed, FDA says clinical data are limited, and it has flagged safety concerns for compounded CJC-1295. If your question is purely technical, with DAC means longer exposure , without DAC means shorter exposure .

What’s the difference between with DAC and without DAC?

The main difference is duration and compound identity . FDA says there are two distinct active moieties being evaluated, CJC-1295 and CJC-1295 DAC, and also notes that naming in the market has been inconsistent. Chemically, DAC adds a maleimidopropionamide-lysine unit that enables albumin binding, which is why DAC versions last much longer.

s a DAC really necessary?

I Necessary, no. Optional, yes. DAC is only necessary if the goal is to create a long-acting version of the peptide. If the goal is a shorter-acting signal, DAC is not necessary. That is the whole purpose of adding it.

What are the side effects of CJC DAC?

In the 2006 healthy-adult study of DAC CJC-1295, no serious adverse reactions were reported . But FDA’s more recent safety review says compounded CJC-1295 may pose risks related to immunogenicity , peptide impurities, and has identified serious adverse events associated with CJC-1295 including increased heart rate and systemic vasodilatory reaction .

What are the disadvantages of DAC?

The main downside is that DAC makes exposure last much longer , so if there is a bad reaction or the effect is not what was intended, it is not easy to “turn off” quickly. It also adds complexity to naming, characterization, and compounding, and FDA specifically highlighted inconsistent naming and peptide-characterization issues as safety concerns. That last point is partly an inference from the long half-life plus FDA’s safety discussion, not a direct trial result.

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Peptide Researches CJC-1295 No DAC 10 MG product image showing the branded box, QR code, purity details, and matching vial on a clean studio background

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CJC-1295 No DAC 10 MG by Peptide Researches displayed with the product box, QR code, purity information, and labeled vial.

CJC-1295 without DAC

CJC-1295 without DAC is a research-grade, lyophilized peptide supplied for controlled laboratory studies involving GHRH-related receptor signaling, assay development, and peptide characterization. Lot-specific COA access and supporting analytical documentation are available through the COA portal. For laboratory research use only. Not for use in humans or animals.

$49.00

All Peptide Researches compounds are supplied strictly for in-vitro research use only. Each batch is tested using High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS), with typical purity ≥ 99% as documented in the accompanying COA.

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Category: Research Compounds

CJC-1295 without DAC is a research-grade, lyophilized peptide supplied for controlled laboratory workflows such as assay development, analytical verification, and peptide characterization. This material is commonly referenced in research settings for GHRH-related receptor signaling studies and comparative pathway readout work under validated laboratory conditions.

Each batch is supported by lot-specific documentation to assist with traceability and experimental recordkeeping. Available records may include Certificate of Analysis data and analytical review files, including HPLC and MS, when released for the batch through the COA portal.

This product is intended for laboratory research environments that require clearly documented peptide material, purity review, and standardized handling context. For laboratory research use only. Not for use in humans or animals. Not intended to diagnose, treat, cure, or prevent any disease.

Product Specifications

Purity (HPLC)	≥99%
Appearance	White to off-white lyophilized powder
Material Type	Research-grade
Molecular Formula	C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight	3367.9 g/mol
CAS Number	446036-97-1
Net Content	Varies by selected variant (choose mg option)
Solubility	See laboratory SOP (solvent selection depends on assay requirements)
Storage (Lyophilized)	Store protected from light and moisture; follow institutional SOPs
Storage (Prepared for assays)	Aliquot as needed; avoid repeated freeze–thaw; follow institutional SOPs
Intended Use	For research use only; not for human or veterinary use
Documentation	Lot-specific COA; analytical data (HPLC/MS) when available

Chemical Identity & Structural Mechanism

Chemical identity

CJC-1295 without DAC is commonly listed in supplier and reference materials as CJC-1295 No DAC, Mod GRF 1-29, or Modified GRF 1-29. It is described as a 29-amino-acid synthetic peptide analog derived from the active N-terminal region of growth hormone-releasing hormone, with a reported molecular formula of C152H252N44O42 and a molecular weight of 3367.9 g/mol. Core Peptides also lists the material as lyophilized powder with purity above 99%, which matches the general specification style used across research-focused product pages.

Structure-activity context

Research references and supplier pages describe CJC-1295 without DAC as a tetra-substituted GRF 1-29 analog. The commonly cited substitutions are D-Ala at position 2, Gln at position 8, Ala at position 15, and Leu at position 27 relative to the shorter GRF 1-29 sequence. These substitutions are typically discussed in structure-focused literature as changes introduced to alter degradation susceptibility and improve sequence stability in laboratory settings. In contrast with CJC-1295 with DAC, the without-DAC form does not include the additional Drug Affinity Complex moiety.

Receptor and signaling context

In research discussions, CJC-1295 without DAC is generally framed as a GHRH-receptor-associated peptide analog. The GHRH receptor is a class B G protein-coupled receptor, and class B receptor signaling is commonly examined through intracellular messenger systems such as cAMP-dependent pathways, receptor trafficking, and downstream phosphorylation readouts in assay models. For that reason, product-page mechanism language is usually best kept at the level of receptor association and assay signaling context, rather than outcome-focused claims.

Assay-dependent characterization

Published descriptions and supplier references show that CJC-1295 without DAC is often discussed in the context of binding studies, signaling readouts, comparative analog profiling, and stability-oriented sequence design. However, the exact assay profile can vary by receptor system, cell background, endpoint selection, and study format. On a product page, it is better to present these points as laboratory characterization context rather than as fixed performance statements.

Chemical structure of CJC-1295 without DAC

Chemical structure of CJC-1295 No DAC shown as a peptide diagram with color-coded atomic markers on a light gray background

CJC-1295 without DAC, also referenced as CJC-1295 No DAC or Mod GRF 1-29, is a 29-amino-acid synthetic peptide analog supplied as a lyophilized research material. It is characterized by a tetra-substituted GRF 1-29 sequence and does not include the DAC moiety found in related variants. Product references commonly describe it by its DAC-free structure, molecular formula, molecular weight, and lyophilized form for laboratory documentation and analytical review.

Research Context & Literature Notes

Alternate names in research references

CJC-1295 without DAC is also listed as CJC-1295 No DAC and Mod GRF 1-29 on supplier pages and reference materials. Core Peptides uses these names together on its product page, which makes them useful identifiers to include in a research-focused section.

Sequence and modification context

Core Peptides describes CJC-1295 without DAC as a synthetic peptide derivative composed of 29 amino acids and presents it as a modified GRF (1-29) sequence. The page also notes that the without-DAC form is structurally distinct because it does not include the added Drug Affinity Complex used in some related variants.

Receptor and assay context

In research discussions, this material is commonly framed in relation to GHRH-receptor-associated studies and laboratory signaling models. A product page can present that context in a neutral way by referring to receptor binding, signaling characterization, and assay readouts rather than outcome-driven language.

Documentation and laboratory review

Core Peptides highlights several technical product signals that are useful for research readers, including lyophilized powder form, purity above 99%, and access points for Certificate of Analysis, HPLC, and Mass Spectrometry. Including this type of documentation language helps the section stay laboratory-focused and strengthens product-page relevance.

Regulatory & Compliance Statement

Laboratory research positioning

This material is presented as a research-use item intended for legitimate laboratory work and not as a consumer-facing product. The product page should maintain a research-first presentation focused on technical review, documentation access, and controlled laboratory workflows.

Product format and documentation

CJC-1295 without DAC is supplied as lyophilized powder and supported by technical documentation relevant to laboratory review. Available records may include Certificate of Analysis, HPLC, and Mass Spectrometry, supporting identity review, batch traceability, and laboratory recordkeeping.

Purchase and access conditions

Product access, ordering, and handling are subject to site terms, age-gating where applicable, and internal laboratory controls. This supports a controlled purchasing environment aligned with research-use positioning.

Intended-use boundary

This material is supplied for in vitro and laboratory workflows only and is not intended for personal, household, or veterinary applications. The product page should keep this boundary clear throughout all technical and descriptive content.

Analytical Documentation

Each batch is analytically verified and supported by a lot-specific Certificate of Analysis (COA). Use the COA portal to access available documentation by product and lot number. Documentation availability may vary by batch.

Storage & Stability

Lyophilized

Store at -20°C for optimal long-term stability (up to 2 years). The lyophilized form is stable at room temperature for brief periods during shipping and handling.

After Reconstitution

Use immediately for best results. If storage is required, aliquot and store at -80°C. Use within 30 days. Avoid repeated freeze-thaw cycles which may degrade peptide integrity.

Shipping Temperature

Products ship in insulated packaging with cold packs when ambient temperatures require it. Lyophilized peptides remain stable during standard transit times.

References

PubChem. CJC1295 Without DAC compound record. PubChem database entry
Martin B, Lopez de Maturana R, Brenneman R, et al. Class II G protein-coupled receptors and their ligands in neuronal function and protection. NeuroMolecular Medicine, 2005. Springer article
Loh HH, Law PY. Second Messengers. Cold Spring Harbor Perspectives in Biology, 2016. CSH Perspectives article
Teichman SL, et al. Prolonged stimulation of growth hormone and insulin-like growth factor I by CJC-1295, a long-acting analog of growth hormone-releasing hormone, in healthy adults. The Journal of Clinical Endocrinology & Metabolism, 2006. Journal page
Zhou F, et al. Structural basis for activation of the growth hormone-releasing hormone receptor. Nature Communications, 2020. Nature article

Research-Only Disclaimer

This product is intended for laboratory research use only (in vitro).

For research use only; not for human or veterinary use.
Not a drug, medicine, or dietary supplement.
Not intended to diagnose, treat, cure, or prevent any disease.
Must be handled by trained research personnel following institutional SOPs.
Purchaser is responsible for compliance with all applicable laws and regulations.

By purchasing this product, you confirm it will be used solely for legitimate research purposes.

Frequently Asked Questions

Neither is universally “better.” DAC and no DAC are better thought of as different pharmacokinetic versions . FDA’s 2024 review treats CJC-1295 and CJC-1295 DAC as distinct active moieties, and the original CJC-1295 DAC work showed DAC was added to prolong exposure by binding to albumin. So with DAC is the longer-acting version; without DAC is the shorter-acting version. Which one is “better” depends on whether you want prolonged exposure or a shorter pulse, not on a clear superiority result.

Storage & Stability

Lyophilized

Store at -20°C for up to 2 years. Stable at RT during shipping.

Reconstituted

Use immediately or store aliquots at -80°C. Use within 30 days.

Quality Assurance

Every batch from Peptide Researches undergoes rigorous HPLC & Mass Spectrometry testing to ensure >99% purity and correct molecular structure verification.

Research Use Only

This product is for laboratory research only. Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease.

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